职称:副研究员 E-mail:993wlc@njucm.edu.cn 主要研究方向:中药活性大分子结构与功能
个人简介
毕业于中国海洋大学,获得理学博士学位,曾在香港大学中医717银娱geg优越会访问学者。研究重点集中在生物大分子与中药多糖成分结构与功能研究领域,擅长多糖大分子的结构分析及产物表征技术,涉及功能性食品与口服给药系统研发方面。迄今为止以第一或通讯作者共发表SCI论文30余篇(>5.0共12篇,单篇最高影响因子11.13,总影响因子合计超过120,他引次数超1000次),发表中文核心论文约60余篇,授权发明专利6项,主持或参与国家自然科学基金等系列项目6项,主持承担或参与横向合作项目10项,参与国家公益行业项目4项,获得国家海洋科技成果2等奖项1项。国家自然科学基金函评专家,Frontiers of Pharmacology的评阅编委,Elsevier和Wiley数据库20余种SCI刊物的认定审稿专家。
承担的主要科研项目
(1) 国家自然科学基金青年项目(30900293),四角蛤蜊粘多糖的结构解析和材料学特性研究,2010/01-2012/12,主持,21万,结题
(2) 江苏省高等学校自然科学研究重大项目(18KJA360008),蛤蜊多糖调控ROS介导肝细胞凋亡的核心糖链及构效,主持,2018/09-2021/08,30万,结题
(3) 国家公益性行业科研专项(201205022-8),五种药源生物活性物质的制备和产业化关键技术研究,参于,2012/01-2017/12,68万,结题
(4) 国家公益性行业科研专项(201305007),江苏沿海低值贝类全值化综合利用关键技术开发与规模化示范,参于,2013/01-2018/12,1968万,结题
(5) 江苏省中医药管理局科研项目(Lz09023),四角蛤蜊活性肽研究,主持,2010/01-2011/12,3万,结题
(6) 现代中药制剂教育部重点实验室开放基金(TCM2020-03),几种高附加值海洋天然产物规模生产关键技术研究与示范,参于,2020/07-2021/12,4万,在研
(7) 校企横向合作项目,“苏峡”黄精药材专属标准建立及相关大健康产品开发,主持,2021/12-2023/12,210万,在研
(8) 校企横向合作项目,中药复方“全真一气汤”多糖的提取工艺优化与初步化学分析,主持,2021/09-2022/12,10万,在研
(9) 艾兰得研发中心科技孵化项目,可改善机体疲劳的黄精多糖固体饮料的研制,主持,2021/03-2022/03,10万,在研
(10) 校企横向合作项目,复方关节注射剂治疗退行性关节炎功效预评价, 主持,2016/09-2017/12,9万,结题
代表性论文
(1) Zhou Bingqian; Zhang Wen; Wu Yujia; Yang Ying; Wang Na; Li Junsong; Fu Tingming; Wang Lingchong; Di Liuqing; Improved efficacy of Panax notoginseng saponin loaded into BSP/alginate microspheres for the treatment of alcoholic gastric ulcers, International Journal of Pharmaceutics, 2021, 596. (期刊论文)
(2) Ying Yang#; Jing Ji#; Liuqing Di; Junsong Li; Lihong Hu; Hongzhi Qiao; Lingchong Wang*; Yibin Feng*; Resource, chemical structure and activity of natural polysaccharides against alcoholic liver damages, Carbohydrate Polymers, 2020, 2020(241): 116355. (期刊论文)
(3) Lingchong Wang#; Ying Yang#; Hor-Yue Tan; Sha Li; Yibin Feng*; Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage, Front. Pharmacol.,, 2020, 11(446): 00446. (期刊论文)
(4) Wu, Yujia#; Zhang, Wen#; Huang, Jianyu; Luo, Zichen; Li, Junsong; Wang, Lingchong*; Di, Liuqing*; Mucoadhesive improvement of alginate microspheres as potential gastroretentive delivery carrier by blending with Bletilla striata polysaccharide, International Journal of Biological Macromolecules, 2019, doi.org/10.1016/(j.ijbiomac.2019.11.1): X1-11. (期刊论文)
(5) Lingchong Wang#; Yujia Wu#; Junsong Li; Hongzhi Qiao; Liuqing Di*; Rheological and mucoadhesive properties of polysaccharide from Bletilla striata with potential use in pharmaceutics as bio-adhesive excipient, International Journal of Biological Macromolecules, 2018, 120(A): 529-536. (期刊论文)
(6) Ling Chong Wang*; Liu Qing Di; Jun Song Li; Li Hong Hu; Jian Ming Cheng; Hao Wu; Elaboration in type, primary structure, and bioactivity of polysaccharides derived from mollusks, Critical Reviews in Food Science and Nutrition, 2019, 59(7): 1091-1114. (期刊论文)
(7) Lingchong Wang*; Liye Chen; Junsong Li; Liqing Di; Hao Wu; Structural elucidation and immune-enhancing activity of peculiar polysaccharides fractioned from marine clam Meretrix meretrix (Linnaeus), Carbohydrate Polymers, 2018, 201: 500-513. (期刊论文)
(8) Wang, Ling Chong; Zhang, Kun; Di, Liu Qing; Liu, Rui; Wu, Hao*; Isolation and structural elucidation of novel homogenous polysaccharide from Mactra veneriformis, Carbohydrate Polymers, 2011, 86(2): 982-987. (期刊论文)
(9) Wang, Ling Chong*; Wu, Hao*; Ji, Jing; Xue, Feng; Liu, Rui; Preparation, analysis and antioxidant evaluation of the controlled product of polysaccharide from Mactra veneriformis by mild acid hydrolysis, Carbohydrate Polymers, 2016, 137(1): 709-718. (期刊论文)
(10) Wang, Lingchong; Di, Liuqing; Liu, Rui; Wu, hao*; Characterizations and microsphere formulation of polysaccharide from the marine clam (Mactra veneriformis), Carbohydrate Polymers, 2013, 92(1): 106-113. (期刊论文)
获得奖项与荣誉
(1) 四角蛤蜊深加工综合利用及功能性保健品的研究开发, 12年海洋科技成果二等奖(第3完成人),证书编号:HK2012-G-2-B57-03
其他成果
(1) Wang, Lingchong*; Wang, Xiangyu; Wu, Hao; Liu, Rui; Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years, MARINE DRUGS, MDPI AG, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 4984-5020, 2014-09. (书籍章节)
(2) 王令充,李俊松,狄留庆,杨颖,嵇晶. 一种抗酒精性肝损伤的白术多糖及其制备方法与应用[P]. CN113185618A,2022-06-11. (授权专利)
(3) 狄留庆,王令充,张雯,周冰倩. 三七白及pH响应性原位凝胶及其制备方法与应用[P]. CN113694144A,2021-11-26. (专利公开)
(4) 吴皓,王令充,狄留庆,常念,程建明,文红梅. 四角蛤蜊提取物及其制备方法和应用[P]. CN101548989B,2012-01-11. (授权专利)